{"id":3159,"date":"2025-10-06T05:52:40","date_gmt":"2025-10-06T05:52:40","guid":{"rendered":"https:\/\/genoks.com.tr\/docs\/fmf-mefv-en\/"},"modified":"2026-05-02T05:05:25","modified_gmt":"2026-05-02T05:05:25","password":"","slug":"fmf-mefv-en","status":"publish","type":"docs","link":"https:\/\/genoks.com.tr\/en\/docs\/fmf-mefv-en\/","title":{"rendered":"Familial Mediterranean Fever | FMF | (MEFV gene)"},"content":{"rendered":"<p><!--genoks-intro-en:start--><\/p>\n<p><strong>Familial Mediterranean Fever (FMF)<\/strong> is the most common autoinflammatory disease in Turkey, caused by mutations in the MEFV gene (16p13.3, pyrin). Carrier frequency ~20% in Turkish population. Clinical features: recurrent fever attacks (12-72h), peritonitis, pleuritis, monoarthritis, erysipelas-like rash. Long-term complication: AA amyloidosis (renal). Treatment: lifelong colchicine prevents attacks and amyloidosis. Resistant cases: anti-IL-1 (anakinra, canakinumab).<\/p>\n<p><!--genoks-intro-en:end--><\/p>\n<p style=\"text-align: justify\"><strong>Ailesel Akdeniz Ate\u015fi | FMF Nedir ?<\/strong><\/p>\n<p style=\"text-align: justify\">Ailesel Akdeniz Ate\u015fi (AAA), otoenflamatuvar bir hastal\u0131kt\u0131r. Genetik bir bozukluk olarak kal\u0131tsal bir \u015fekilde aktar\u0131l\u0131r. Hastal\u0131\u011f\u0131n belirtileri aras\u0131nda y\u00fcksek ate\u015f, kar\u0131n a\u011fr\u0131s\u0131, eklem a\u011fr\u0131s\u0131, bulant\u0131, kusma, ba\u015f a\u011fr\u0131s\u0131, deride k\u0131zar\u0131kl\u0131k ve halsizlik yer al\u0131r. AAA, Akdeniz \u00fclkelerinde ve Orta Do\u011fu&#8217;da s\u0131k g\u00f6r\u00fclen bir hastal\u0131kt\u0131r. AAA MEFV genindeki mutasyonlar sonucu ba\u011f\u0131\u015f\u0131kl\u0131k sistemi yan\u0131t\u0131n\u0131n bozulmas\u0131 ve v\u00fccutta iltihaplanmayla ortaya \u00e7\u0131kar. Hastal\u0131k genellikle \u00e7ocukluk veya ergenlik \u00e7a\u011f\u0131nda ba\u015flar ve ya\u015fam boyu devam eder. AAA tedavisi, semptomlar\u0131n hafifletilmesine ve ataklar\u0131n azalt\u0131lmas\u0131na y\u00f6nelik y\u00f6netimsel tedavilerle yap\u0131l\u0131r. Ancak, tedavi edilmezse, hastal\u0131k ciddi sonu\u00e7lara neden olabilir ve \u00f6zellikle b\u00f6breklerde kal\u0131c\u0131 hasara yol a\u00e7abilir.<\/p>\n<p style=\"text-align: justify\"><strong>Otoenflamatuvar nedir?<\/strong><br \/>\nOtoenflamatuvar, v\u00fccudun kendi kendine iltihaplanmas\u0131 anlam\u0131na gelir. Normal \u015fartlarda, ba\u011f\u0131\u015f\u0131kl\u0131k sistemi, enfeksiyonlara, yaralanmalara veya di\u011fer zararl\u0131 durumlara kar\u015f\u0131 tepki verir ve v\u00fccudu korumaya \u00e7al\u0131\u015f\u0131r. Ancak otoenflamatuvar hastal\u0131klarda, ba\u011f\u0131\u015f\u0131kl\u0131k sistemi yanl\u0131\u015fl\u0131kla kendi dokular\u0131n\u0131 sald\u0131r\u0131r ve v\u00fccutta iltihaplanmaya neden olur. Bu durum, \u00e7e\u015fitli semptomlara ve uzun vadeli hasara yol a\u00e7abilir.<\/p>\n<table>\n<tbody>\n<tr>\n<td><strong>Gen :<\/strong><\/td>\n<td>MEFV<\/td>\n<\/tr>\n<tr>\n<td><strong>Y\u00f6ntem :<\/strong><\/td>\n<td>T\u00fcm Gen Dizi Analizi<\/td>\n<\/tr>\n<tr>\n<td><strong>Raporlama S\u00fcresi :<\/strong><\/td>\n<td>8 Hafta (+\/- 2 Hafta)<\/td>\n<\/tr>\n<tr>\n<td><strong><strong>Prenatal\/ Postnatal:<\/strong><\/strong><\/td>\n<td>Postnatal<\/td>\n<\/tr>\n<tr>\n<td><strong>Gerekli Numune<\/strong>:<\/td>\n<td>EDTA&#8217;l\u0131 Kan (2-4 ml)<\/td>\n<\/tr>\n<tr>\n<td><strong>Saklama \/ Ta\u015f\u0131ma S\u0131cakl\u0131\u011f\u0131:<\/strong><\/td>\n<td>+ 4C\u00b0\/ + 24C\u00b0<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>T\u00fcm genetik testlerimiz <strong>&#8220;Hasta Onam Formu&#8221;<\/strong> ve <strong>&#8220;KVKK Formu&#8221;<\/strong>nun imzalanmas\u0131n\u0131n ard\u0131ndan \u00e7al\u0131\u015f\u0131lmaya ba\u015flan\u0131r.<\/p>\n<hr \/>\n<p><strong>Detayl\u0131 Bilgi Almak \u0130\u00e7in Bize Mesaj Atabilirsiniz.<\/strong><\/p>\n<table>\n<tbody>\n<tr>\n<td>[contact-form-7 id=&#8221;710&#8243; title=&#8221;genetik ba\u015fvuru&#8221;]<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Genoks Genetik Hastal\u0131klar De\u011ferlendirme Merkezi T.C. Sa\u011fl\u0131k Bankanl\u0131\u011f\u0131nca denetlenen ve GHDM-SM\/06.15\/01 ruhsat numaras\u0131 ile hizmet veren sa\u011fl\u0131k kurulu\u015fudur. genoks.com.tr web sayfas\u0131nda bulunan bilgiler, genetik de\u011ferlendirme ve\/veya tan\u0131-te\u015fhis ama\u00e7l\u0131 kullan\u0131lmamal\u0131d\u0131r. T\u00fcm i\u00e7erikler bilgilendirme ama\u00e7l\u0131d\u0131r.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Familial Mediterranean Fever (FMF) is the most common autoinflammatory disease in Turkey, caused by mutations in the MEFV gene (16p13.3, pyrin). Carrier frequency ~20% in Turkish population. Clinical features: recurrent fever attacks (12-72h), peritonitis, pleuritis, monoarthritis, erysipelas-like rash. Long-term complication:<span class=\"excerpt-hellip\"> [\u2026]<\/span><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","template":"","meta":{"footnotes":""},"doc_category":[204],"doc_tag":[86,101,117,118,119,128],"class_list":["post-3159","docs","type-docs","status-publish","hentry","doc_category-genoks-gdhm-genetic-tests","doc_tag-ailesel-akdeniz-atesi","doc_tag-fmf","doc_tag-non-steroid-anti-inflammatory-drugs","doc_tag-nsaid-nedir","doc_tag-otoenflamatuvar","doc_tag-steroid-olmayan-anti-enflamatuar-ilaclar"],"aioseo_notices":[],"year_month":"2026-05","word_count":397,"total_views":0,"reactions":{"happy":0,"normal":0,"sad":0},"author_info":{"name":"admin","author_nicename":"admin","author_url":"https:\/\/genoks.com.tr\/en\/author\/admin\/"},"doc_category_info":[{"term_name":"Genoks GDHM Genetic Tests","term_url":"https:\/\/genoks.com.tr\/en\/docs-category\/genoks-gdhm-genetic-tests\/"}],"doc_tag_info":[{"term_name":"Ailesel Akdeniz Ate\u015fi","term_url":"https:\/\/genoks.com.tr\/docs-tag\/ailesel-akdeniz-atesi\/"},{"term_name":"FMF","term_url":"https:\/\/genoks.com.tr\/docs-tag\/fmf\/"},{"term_name":"Non-Steroid Anti-Inflammatory Drugs","term_url":"https:\/\/genoks.com.tr\/docs-tag\/non-steroid-anti-inflammatory-drugs\/"},{"term_name":"NSAID Nedir?","term_url":"https:\/\/genoks.com.tr\/docs-tag\/nsaid-nedir\/"},{"term_name":"Otoenflamatuvar","term_url":"https:\/\/genoks.com.tr\/docs-tag\/otoenflamatuvar\/"},{"term_name":"steroid olmayan anti-enflamatuar ila\u00e7lar","term_url":"https:\/\/genoks.com.tr\/docs-tag\/steroid-olmayan-anti-enflamatuar-ilaclar\/"}],"aioseo_head":"\n\t\t<!-- All in One SEO Pro 4.9.5.2 - aioseo.com -->\n\t<meta name=\"description\" content=\"Familial Mediterranean Fever (FMF) is the most common autoinflammatory disease in Turkey, caused by mutations in the MEFV gene (16p13.3, pyrin). Carrier frequency ~20% in Turkish population. Clinical features: recurrent fever attacks (12-72h), peritonitis, pleuritis, monoarthritis, erysipelas-like rash. Long-term complication: AA amyloidosis (renal). Treatment: lifelong colchicine prevents attacks and amyloidosis. 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Resistant cases: anti-IL-1 (anakinra, canakinumab).","inLanguage":"en-US","isPartOf":{"@id":"https:\/\/genoks.com.tr\/en\/#website"},"breadcrumb":{"@id":"https:\/\/genoks.com.tr\/en\/docs\/fmf-mefv-en\/#breadcrumblist"},"author":{"@id":"https:\/\/genoks.com.tr\/en\/author\/admin\/#author"},"creator":{"@id":"https:\/\/genoks.com.tr\/en\/author\/admin\/#author"},"datePublished":"2025-10-06T05:52:40+00:00","dateModified":"2026-05-02T05:05:25+00:00"},{"@type":"WebSite","@id":"https:\/\/genoks.com.tr\/en\/#website","url":"https:\/\/genoks.com.tr\/en\/","name":"Genoks Genetics | NIPT, Carrier Screening, Oncogenetics and WES Services","description":"Shedding Light on Your Genes!","inLanguage":"en-US","publisher":{"@id":"https:\/\/genoks.com.tr\/en\/#organization"}}]},"og:locale":"en_US","og:site_name":"Genoks Genetics | NIPT, Carrier Screening, Oncogenetics and WES Services - Shedding Light on Your Genes!","og:type":"article","og:title":"Familial Mediterranean Fever | FMF | (MEFV gene) - Genoks Genetics | NIPT, Carrier Screening, Oncogenetics and WES Services","og:description":"Familial Mediterranean Fever (FMF) is the most common autoinflammatory disease in Turkey, caused by mutations in the MEFV gene (16p13.3, pyrin). Carrier frequency ~20% in Turkish population. Clinical features: recurrent fever attacks (12-72h), peritonitis, pleuritis, monoarthritis, erysipelas-like rash. Long-term complication: AA amyloidosis (renal). Treatment: lifelong colchicine prevents attacks and amyloidosis. Resistant cases: anti-IL-1 (anakinra, canakinumab).","og:url":"https:\/\/genoks.com.tr\/en\/docs\/fmf-mefv-en\/","og:image":"https:\/\/genoks.com.tr\/wp-content\/uploads\/2025\/06\/genoks.svg","og:image:secure_url":"https:\/\/genoks.com.tr\/wp-content\/uploads\/2025\/06\/genoks.svg","article:published_time":"2025-10-06T05:52:40+00:00","article:modified_time":"2026-05-02T05:05:25+00:00","article:publisher":"https:\/\/www.facebook.com\/GenoksGHTM","twitter:card":"summary_large_image","twitter:site":"@Genoks_GHTM","twitter:title":"Familial Mediterranean Fever | FMF | (MEFV gene) - Genoks Genetics | NIPT, Carrier Screening, Oncogenetics and WES Services","twitter:description":"Familial Mediterranean Fever (FMF) is the most common autoinflammatory disease in Turkey, caused by mutations in the MEFV gene (16p13.3, pyrin). Carrier frequency ~20% in Turkish population. Clinical features: recurrent fever attacks (12-72h), peritonitis, pleuritis, monoarthritis, erysipelas-like rash. Long-term complication: AA amyloidosis (renal). Treatment: lifelong colchicine prevents attacks and amyloidosis. Resistant cases: anti-IL-1 (anakinra, canakinumab).","twitter:creator":"@Genoks_GHTM","twitter:image":"https:\/\/genoks.com.tr\/wp-content\/uploads\/2025\/06\/genoks.svg"},"aioseo_meta_data":{"post_id":"3159","title":null,"description":null,"keywords":null,"keyphrases":null,"primary_term":null,"canonical_url":null,"og_title":null,"og_description":null,"og_object_type":"default","og_image_type":"default","og_image_url":null,"og_image_width":null,"og_image_height":null,"og_image_custom_url":null,"og_image_custom_fields":null,"og_video":null,"og_custom_url":null,"og_article_section":null,"og_article_tags":null,"twitter_use_og":false,"twitter_card":"default","twitter_image_type":"default","twitter_image_url":null,"twitter_image_custom_url":null,"twitter_image_custom_fields":null,"twitter_title":null,"twitter_description":null,"schema":{"blockGraphs":[],"customGraphs":[],"default":{"data":{"Article":[],"Course":[],"Dataset":[],"FAQPage":[],"Movie":[],"Person":[],"Product":[],"ProductReview":[],"Car":[],"Recipe":[],"Service":[],"SoftwareApplication":[],"WebPage":[]},"graphName":"","isEnabled":true},"graphs":[]},"schema_type":"default","schema_type_options":null,"pillar_content":false,"robots_default":true,"robots_noindex":false,"robots_noarchive":false,"robots_nosnippet":false,"robots_nofollow":false,"robots_noimageindex":false,"robots_noodp":false,"robots_notranslate":false,"robots_max_snippet":null,"robots_max_videopreview":null,"robots_max_imagepreview":"large","priority":null,"frequency":null,"local_seo":null,"seo_analyzer_scan_date":"2026-05-02 06:00:42","breadcrumb_settings":null,"limit_modified_date":false,"reviewed_by":null,"open_ai":null,"ai":null,"created":"2026-05-01 14:34:30","updated":"2026-05-02 06:00:42"},"aioseo_breadcrumb":"<div class=\"aioseo-breadcrumbs\"><span class=\"aioseo-breadcrumb\">\n\t<a href=\"https:\/\/genoks.com.tr\/en\/\" title=\"Home\">Home<\/a>\n<\/span><span class=\"aioseo-breadcrumb-separator\">&raquo;<\/span><span class=\"aioseo-breadcrumb\">\n\t<a href=\"https:\/\/genoks.com.tr\/en\/Genoks\/\" title=\"Dok\u00fcmanlar\">Dok\u00fcmanlar<\/a>\n<\/span><span class=\"aioseo-breadcrumb-separator\">&raquo;<\/span><span class=\"aioseo-breadcrumb\">\n\t<a href=\"https:\/\/genoks.com.tr\/en\/docs-category\/genoks-gdhm-genetic-tests\/\" title=\"Genoks GDHM Genetic Tests\">Genoks GDHM Genetic Tests<\/a>\n<\/span><span class=\"aioseo-breadcrumb-separator\">&raquo;<\/span><span class=\"aioseo-breadcrumb\">\n\tFamilial Mediterranean Fever | FMF | (MEFV gene)\n<\/span><\/div>","aioseo_breadcrumb_json":[{"label":"Home","link":"https:\/\/genoks.com.tr\/en\/"},{"label":"Dok\u00fcmanlar","link":"https:\/\/genoks.com.tr\/en\/Genoks\/"},{"label":"Genoks GDHM Genetic Tests","link":"https:\/\/genoks.com.tr\/en\/docs-category\/genoks-gdhm-genetic-tests\/"},{"label":"Familial Mediterranean Fever | FMF | (MEFV gene)","link":"https:\/\/genoks.com.tr\/en\/docs\/fmf-mefv-en\/"}],"_links":{"self":[{"href":"https:\/\/genoks.com.tr\/en\/wp-json\/wp\/v2\/docs\/3159","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/genoks.com.tr\/en\/wp-json\/wp\/v2\/docs"}],"about":[{"href":"https:\/\/genoks.com.tr\/en\/wp-json\/wp\/v2\/types\/docs"}],"author":[{"embeddable":true,"href":"https:\/\/genoks.com.tr\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/genoks.com.tr\/en\/wp-json\/wp\/v2\/comments?post=3159"}],"version-history":[{"count":1,"href":"https:\/\/genoks.com.tr\/en\/wp-json\/wp\/v2\/docs\/3159\/revisions"}],"predecessor-version":[{"id":3467,"href":"https:\/\/genoks.com.tr\/en\/wp-json\/wp\/v2\/docs\/3159\/revisions\/3467"}],"wp:attachment":[{"href":"https:\/\/genoks.com.tr\/en\/wp-json\/wp\/v2\/media?parent=3159"}],"wp:term":[{"taxonomy":"doc_category","embeddable":true,"href":"https:\/\/genoks.com.tr\/en\/wp-json\/wp\/v2\/doc_category?post=3159"},{"taxonomy":"doc_tag","embeddable":true,"href":"https:\/\/genoks.com.tr\/en\/wp-json\/wp\/v2\/doc_tag?post=3159"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}