{"id":3292,"date":"2025-10-06T05:52:40","date_gmt":"2025-10-06T05:52:40","guid":{"rendered":"https:\/\/genoks.com.tr\/docs\/hereditary-cancer-genoxhere-en\/"},"modified":"2026-05-01T21:43:16","modified_gmt":"2026-05-01T21:43:16","password":"","slug":"hereditary-cancer-genoxhere-en","status":"publish","type":"docs","link":"https:\/\/genoks.com.tr\/en\/docs\/hereditary-cancer-genoxhere-en\/","title":{"rendered":"What is Hereditary Cancer and GenoXhere?"},"content":{"rendered":"<p><!--genoks-intro-en:start--><\/p>\n<p><strong>What is Hereditary Cancer and GenoXhere?<\/strong><\/p>\n<p>Approximately 5-10% of all cancers arise on a hereditary background \u2014 pathogenic germline variants in cancer-predisposing genes that are inherited from a parent. Hallmark features of hereditary cancer include young age of onset, multiple primary cancers in the same individual, multiple affected family members across generations, and rare\/specific cancer types (e.g. male breast cancer, medullary thyroid cancer, retinoblastoma). Identification of hereditary cancer enables targeted surveillance, risk-reducing surgery, chemoprevention, and access to molecularly targeted therapy (e.g. PARP inhibitors for BRCA-related cancers).<\/p>\n<p><strong>The GenoXhere oncology panel<\/strong> provides comprehensive germline analysis of high- and moderate-penetrance cancer-predisposing genes including BRCA1, BRCA2, PALB2, ATM, CHEK2, TP53, PTEN, CDH1, STK11, MLH1, MSH2, MSH6, PMS2, EPCAM, APC, MUTYH, VHL, RET, MEN1, and others. The panel is offered in two configurations: <strong>Prime 160 genes<\/strong> for general hereditary cancer assessment and <strong>Plus 360 genes<\/strong> for extended hematologic and rare-cancer coverage. Sample: 2-4 mL EDTA peripheral blood. Reporting time: 8 weeks (\u00b12). Results are interpreted by ACMG\/AMP 2015 variant classification, and post-test genetic counseling is mandatory.<\/p>\n<p><!--genoks-intro-en:end--><\/p>\n<p style=\"text-align: justify\"><strong>Herediter Kanser Nedir?<\/strong><\/p>\n<p style=\"text-align: justify\">Herediter kanser, bir ki\u015finin genetik materyalindeki belirli bir mutasyon nedeniyle kansere yakalanma riskinin artt\u0131\u011f\u0131 bir t\u00fcr kanserdir. Bu mutasyonlar, bir ki\u015finin do\u011fumundan itibaren var olan genetik de\u011fi\u015fikliklerdir ve bu de\u011fi\u015fiklikler kanser h\u00fccrelerinin geli\u015fmesine ve b\u00fcy\u00fcmesine neden olabilir. GenoXhere ise heretider kanserlere kar\u015f\u0131 Genoks Genetik Hastal\u0131klar De\u011ferlendirme Merkezi&#8217;nin onkoloji panelidir.<\/p>\n<p style=\"text-align: justify\">Herediter kanser, \u00f6zellikle ailede birden fazla kanser vakas\u0131n\u0131n g\u00f6r\u00fcld\u00fc\u011f\u00fc durumlarda d\u00fc\u015f\u00fcn\u00fclmelidir. \u00d6rne\u011fin, meme kanseri, over kanseri, kolon kanseri, pankreas kanseri ve baz\u0131 l\u00f6semi t\u00fcrleri gibi baz\u0131 kanserler, herediter kanser sendromlar\u0131na neden olabilir.<\/p>\n<p style=\"text-align: justify\">Herediter kanser sendromlar\u0131, \u00f6zellikle kanser geli\u015fimi a\u00e7\u0131s\u0131ndan y\u00fcksek risk ta\u015f\u0131yan ki\u015filer i\u00e7in d\u00fczenli taramalar ve erken te\u015fhisin sa\u011flanmas\u0131na yard\u0131mc\u0131 olacak genetik testler yoluyla tan\u0131mlanabilir. Bu ki\u015filer, kanser geli\u015fimi a\u00e7\u0131s\u0131ndan risk alt\u0131nda olduklar\u0131 i\u00e7in, sa\u011fl\u0131kl\u0131 ya\u015fam tarz\u0131 de\u011fi\u015fiklikleri, d\u00fczenli taramalar ve gerekirse tedavi se\u00e7enekleri gibi \u00f6nlemler alarak kanser risklerini azaltabilirler.<\/p>\n<p style=\"text-align: justify\"><strong>GenoXhere Nedir?<\/strong><br \/>\nGenoXhere; heretider kanserlere kar\u015f\u0131 Genoks Genetik Hastal\u0131klar De\u011ferlendirme Merkezi&#8217;nin onkoloji panelidir. GenoXhere, <a href=\"https:\/\/genoks.com.tr\/genetik_bilgi_bankas\u0131\/genoxhere-prostat-kanseri\/\">GenoXhere Prostat<\/a>, <a href=\"https:\/\/genoks.com.tr\/genetik_bilgi_bankas\u0131\/genoxhere-meme-over-kanseri\/\">Genoks Meme \/ Over<\/a>, <a href=\"https:\/\/genoks.com.tr\/genetik_bilgi_bankas\u0131\/genoxhere-kolon-23-gen\/\">GenoXhere Kolon 23 Gen<\/a> ve <a href=\"https:\/\/genoks.com.tr\/genetik_bilgi_bankas\u0131\/genoxhere-brca\/\">GenoXhere BRCA<\/a> panellerinin yan\u0131 s\u0131ra Prime 160 Gen ve Plus 360 Gen olmak \u00fczere iki farkl\u0131 paket ile sunulmaktad\u0131r.<\/p>\n<p style=\"text-align: justify\"><strong>GenoXhere Prime 160 Gen <\/strong><\/p>\n<table>\n<tbody>\n<tr>\n<td><strong>Gen :<\/strong><\/td>\n<td>ABCB11 | AIP | ALK | ANKRD26 | APC | ATM | ATR | AXIN2 | BAP1 | BARD1 | BLM | BMPR1A | BRAF | BRCA1, BRCA2 | BRIP1 | CASR | CBL | CDC73 | CDH1 | CDK4 | CDKN1B | CDKN1C | CDKN2A | CEBPA | CEBPE | CEP57 | CFTR | CHEK2 | COL7A1 | CTC1 | CTRC | CYLD | DDB2 | DICER1 | DIS3L2 | DKC1 | DOCK8 | EGFR | EGLN1 | ELANE | EPCAM | ERCC1 | ERCC2 | ERCC3 | ERCC4 | ERCC5 | EXO1 | EXT1 | EXT2 | EZH2 | FAH | FANCA | FANCB | FANCC | FANCD2 | FANCE | FANCF | FANCG | FANCI | FANCL | FANCM | FH | FLCN | G6PC3 | GALNT12 | GATA2 | GBA | GJB2 | GPC3 | GREM1 | HAX1 | HFE | HMBS | HNF1A | HOXB13 | HRAS | ITK | KIF1B | KIT | KITLG | KRAS| MAP2K1 | MAP2K2 | MAX | MC1R | MEN1 | MET | MITF | MLH1 | MLH3 | MPL | MRE11 | MRE11A | MSH2 | MSH3 | MSH6 | MTAP | MUTYH | NBN | NF1 | NF2 | NHP2 | NOP10 | NPAT | NRAS | NSD1 | NSUN2 | NTHL1 | PALB2| PALLD | PAX5 | PDGFRA | PHOX2B | PMS1 | PMS2 | POLD1 | POLH | PPM1D | PRF1 | PRKAR1A | PRSS1 | PTCH1 | PTCH2 | PTEN | PTPN11 | RAD50 | RAD51C | RAD51D | RAF1 | RB1 | RECQL4 | RET | RHBDF2 | RMRP | RUNX1 | SAMD9 | SBDS | SDHA | SDHAF2 | SDHB | SDHC | SDHD | SERPINA1 | SH2D1A | SHOC2 | SLC25A13 | SLC45A2 | SLX4 | SMAD4 | SMARCA4 | SMARCB1 | SMARCE1 | SOS1 | SPINK1 | SPRED1 | SRP72 | STK11 | SUFU | TERC | TERT| TINF2 | TMEM127 | TP53 | TSC1 | TSC2 | TYR | VHL | WRAP53 | WRN | WT1 | XPA | XPC | XRCC2 | XRCC2<\/td>\n<\/tr>\n<tr>\n<td><strong>Y\u00f6ntem :<\/strong><\/td>\n<td>NGS<\/td>\n<\/tr>\n<tr>\n<td><strong>Raporlama S\u00fcresi :<\/strong><\/td>\n<td>8 Hafta (+\/- 2 Hafta)<\/td>\n<\/tr>\n<tr>\n<td><strong><strong>Prenatal\/ Postnatal:<\/strong><\/strong><\/td>\n<td>Postnatal<\/td>\n<\/tr>\n<tr>\n<td><strong>Gerekli Numune<\/strong>:<\/td>\n<td>EDTA&#8217;l\u0131 Kan (2-4 ml)<\/td>\n<\/tr>\n<tr>\n<td><strong>Saklamama \/ Ta\u015f\u0131ma S\u0131cakl\u0131\u011f\u0131:<\/strong><\/td>\n<td>+ 4C\u00b0\/ + 24C\u00b0<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<hr \/>\n<p style=\"text-align: justify\"><strong>GenoXhere Plus 360 Gen <\/strong><\/p>\n<table>\n<tbody>\n<tr>\n<td><strong>Gen :<\/strong><\/td>\n<td>ABCA3 | ABCB7 | ABCG5 | ABCG8 | ACD | ACTB | ACTN1 | ADAMTS13 | AIP | AK1 | AK2 | ALAS2 | ALK | AMN | ANK1 | ANKRD26 | AP3B1 | AP3D1 | APC | ARPC1B | ATM | ATR | ATRX | AXIN2 | BAP1 | BARD1 | BLM | BLOC1S3 | BLOC1S6 | BMPR1A | BRAF | BRCA1 | BRCA2 | BRIP1 | BUB1B | C15ORF41 | C6ORF25 | CBL | CD59 | CD70 | CDAN1 | CDC42 | CDC73 | CDH1 | CDK4 | CDKN1B | CDKN1C | CDKN2A | CEBPA | CECR1 | CEP57 | CHEK2| CLCN7 | CLPB | CSF2RA | CSF3R | CTC1 | CTLA4 | CTNNA1 | CTSC | CUBN | CXCR4 | CYB5R3 | CYCS | CYLD | DDB2 | DDX41 | DHFR | DICER1 | DIS3L2 | DKC1 | DNAJC21 | DNASE2 | DTNBP1 | EFL1 | EGFR | EGLN1 | ELANE | EPAS1 | EPB41 | EPB42 | EPCAM | EPOR | ERCC1 | ERCC2 | ERCC3 | ERCC4 | ERCC5 | ERCC6L2 | ETV6 | EXO1 | EXT1 | EXT2 | EZH2 | F10 | F11 | F12 | F13A1 | F13B | F2 | F5 | F7 | F8 | F9 | FADD | FAM111B | FANCA | FANCB | FANCC | FANCD2 | FANCE | FANCF | FANCG | FANCI | FANCL | FANCM | FAS | FASLG | FGA | FGB | FGG | FH | FLCN | FLI1 | FLNA | FYB | G6PC3 | G6PD | GALNT12 | GATA1 | GATA2 | GBA | GCLC | GFI1 | GFI1B | GGCX | GINS1 | GLRX5 | GP1BA | GP9 | GPC3 | GPI | GPR101 | GPR143 | GREM1 | GSS | HAVCR2 | HAX1 | HBA1 | HBA2 | HBB | HFE | HK1 | HMOX1 | HNF1A | HOXA11 | HOXB13 | HPS1 | HPS3 | HPS4 | HPS5 | HPS6 | HRAS | IFNGR2 | IKZF1 | ITGA2 | ITGA2B | ITGB3 | ITK | JAGN1 | JAK2 | KCNN4 | KIF1B | KIF23 | KIT | KITLG | KLF1 | KRAS | LAMTOR2 | LMAN1 | LPIN2 | LYST | LZTR1 | MAGT1 | MAP2K1 | MAP2K2 | MASTL | MAX | MCFD2 | MECOM | MEN1 | MET | MITF | MKL1 | MLH1 | MLH3 | MPL | MRE11A | MSH2 | MSH3 | MSH6 | MTHFD1 | MTR | MUTYH | MYH9 | MYO5A | NAF1 | NBEAL2 | NBN | NF1 | NF2 | NHP2 | NOP10 | NRAS | NSD1 | NSUN2 | NT5C3A | NTHL1 | OBFC1 | 37257 | P2RY12 | PALB2 | PARN | PAX5 | PC | PDGFRA | PDHA1 | PDHX | PGK1 | PGM3 | PHOX2B | PIEZO1 | PKLR | PMS1 | PMS2 | POLD1 | POLE | POLH | POT1 | PPM1D | PRF1 | PRKACG | PRKAR1A | PROC | PROS1 | PTCH1 | PTEN | PTPN11 | PUS1 | RAB27A | RAC2 | RAD50 | RAD51C | RAD51D | RAF1 | RASA2 | RASGRP2 | RB1 | RBM8A | RECQL | RECQL4 | REN | REST | RET | RHAG | RHBDF2 | RIT1 | RNF168 | RPL11 | RPL15 | RPL26 | RPL27 | RPL31 | RPL35A | RPL5 | RPS10 | RPS19 | RPS20 | RPS24 | RPS26 | RPS28 | RPS29 | RPS7 | RRAS | RTEL1 | RUNX1 | SAMD9 | SAMD9L | SBDS | SDHA | SDHAF2 | SDHB | SDHC | SDHD | SEC23B | SERPINC1 | SERPINF2 | SFTPB | SFTPC | SH2D1A | SHOC2 | SLC11A2 | SLC19A2 | SLC25A38 | SLC37A4 | SLC45A2 | SLC46A1 | SLC4A1 | SLFN14 | SLX4 | SMAD4 | SMARCA4 | SMARCB1 | SMARCD2 | SMARCE1 | SOS1 | SOS2 | SPRED1 | SPTA1 | SPTB | SRC | SRP54 | SRP72 | STAT3 | STK11 | STX11 | STXBP2 | SUFU | TBXA2R | TBXAS1 | TCN2 | TERC | TERT | TF | THBD | THPO | TINF2 | TMEM127 | TMPRSS6 | TP53 | TPI1 | TRIP13 | TRNT1 | TSC1 | TSC2 | TUBB1 | TYR | TYRP1 | UBE2T | UNC13D | USB1 | VHL | VKORC1 | VPS13B | VPS45 | VWF | WAS | WDR1 | WIPF1 | WRAP53 | WRN<\/td>\n<\/tr>\n<tr>\n<td><strong>Y\u00f6ntem :<\/strong><\/td>\n<td>NGS<\/td>\n<\/tr>\n<tr>\n<td><strong>Raporlama S\u00fcresi :<\/strong><\/td>\n<td>8 Hafta (+\/- 2 Hafta)<\/td>\n<\/tr>\n<tr>\n<td><strong><strong>Prenatal\/ Postnatal:<\/strong><\/strong><\/td>\n<td>Postnatal<\/td>\n<\/tr>\n<tr>\n<td><strong>Gerekli Numune<\/strong>:<\/td>\n<td>EDTA&#8217;l\u0131 Kan (2-4 ml)<\/td>\n<\/tr>\n<tr>\n<td><strong>Saklamama \/ Ta\u015f\u0131ma S\u0131cakl\u0131\u011f\u0131:<\/strong><\/td>\n<td>+ 4C\u00b0\/ + 24C\u00b0<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<hr \/>\n<p><strong>Detayl\u0131 Bilgi Almak \u0130\u00e7in Bize Mesaj Atabilirsiniz.<\/strong><\/p>\n<table>\n<tbody>\n<tr>\n<td>[contact-form-7 id=&#8221;710&#8243; title=&#8221;genetik ba\u015fvuru&#8221;]<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Genoks Genetik Hastal\u0131klar De\u011ferlendirme Merkezi T.C. Sa\u011fl\u0131k Bankanl\u0131\u011f\u0131nca denetlenen ve GHDM-SM\/06.15\/01 ruhsat numaras\u0131 ile hizmet veren sa\u011fl\u0131k kurulu\u015fudur. genoks.com.tr web sayfas\u0131nda bulunan bilgiler, genetik de\u011ferlendirme ve\/veya tan\u0131-te\u015fhis ama\u00e7l\u0131 kullan\u0131lmamal\u0131d\u0131r. T\u00fcm i\u00e7erikler bilgilendirme ama\u00e7l\u0131d\u0131r.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>What is Hereditary Cancer and GenoXhere? Approximately 5-10% of all cancers arise on a hereditary background \u2014 pathogenic germline variants in cancer-predisposing genes that are inherited from a parent. Hallmark features of hereditary cancer include young age of onset, multiple<span class=\"excerpt-hellip\"> [\u2026]<\/span><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","template":"","meta":{"footnotes":""},"doc_category":[204],"doc_tag":[92,105,106,116,122],"class_list":["post-3292","docs","type-docs","status-publish","hentry","doc_category-genoks-gdhm-genetic-tests","doc_tag-brca","doc_tag-kalitsal","doc_tag-kanser","doc_tag-mutasyon","doc_tag-postnatal"],"aioseo_notices":[],"year_month":"2026-05","word_count":1140,"total_views":0,"reactions":{"happy":0,"normal":0,"sad":0},"author_info":{"name":"admin","author_nicename":"admin","author_url":"https:\/\/genoks.com.tr\/en\/author\/admin\/"},"doc_category_info":[{"term_name":"Genoks GDHM Genetic Tests","term_url":"https:\/\/genoks.com.tr\/en\/docs-category\/genoks-gdhm-genetic-tests\/"}],"doc_tag_info":[{"term_name":"BRCA","term_url":"https:\/\/genoks.com.tr\/docs-tag\/brca\/"},{"term_name":"Kal\u0131tsal","term_url":"https:\/\/genoks.com.tr\/docs-tag\/kalitsal\/"},{"term_name":"kanser","term_url":"https:\/\/genoks.com.tr\/docs-tag\/kanser\/"},{"term_name":"Mutasyon","term_url":"https:\/\/genoks.com.tr\/docs-tag\/mutasyon\/"},{"term_name":"Postnatal","term_url":"https:\/\/genoks.com.tr\/docs-tag\/postnatal\/"}],"aioseo_head":"\n\t\t<!-- All in One SEO Pro 4.9.5.2 - aioseo.com -->\n\t<meta name=\"description\" content=\"What is Hereditary Cancer and GenoXhere?Approximately 5-10% of all cancers arise on a hereditary background \u2014 pathogenic germline variants in cancer-predisposing genes that are inherited from a parent. 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