{"id":3320,"date":"2025-10-06T05:52:40","date_gmt":"2025-10-06T05:52:40","guid":{"rendered":"https:\/\/genoks.com.tr\/docs\/rett-syndrome-en\/"},"modified":"2026-05-02T05:14:21","modified_gmt":"2026-05-02T05:14:21","password":"","slug":"rett-syndrome-en","status":"publish","type":"docs","link":"https:\/\/genoks.com.tr\/en\/docs\/rett-syndrome-en\/","title":{"rendered":"What is Rett Syndrome? How does it Manifest?"},"content":{"rendered":"<p><!--genoks-intro-en:start--><\/p>\n<p><strong>Rett Syndrome.<\/strong> X-linked dominant neurodevelopmental disorder caused by mutations in the MECP2 gene, primarily affecting females (almost lethal in males prenatally). Classic features: normal early development (6-18 months), then regression with loss of purposeful hand use, stereotypic hand-wringing, gait apraxia, microcephaly, seizures, autonomic dysfunction. Diagnosis: clinical criteria (Neul 2010) + MECP2 sequencing\/MLPA. Treatment: supportive multidisciplinary care, trofinetide (FDA-approved 2023).<\/p>\n<p><!--genoks-intro-en:end--><\/p>\n<p style=\"text-align: justify\">Rett Sendromu X kromozomu \u00fczerinde bulunan MECP2 gen mutasyonlar\u0131na ba\u011fl\u0131 olarak ortaya \u00e7\u0131kan n\u00f6rolojik bozukluktur. Hemen hemen her zaman k\u0131z \u00e7ocuklarda g\u00f6r\u00fcl\u00fcr, bozukluk olan erkek fet\u00fcsler nadiren do\u011far. Rett Sendromu durumunda do\u011fum s\u0131ras\u0131nda herhangi bir sorun olmamas\u0131na ra\u011fmen\u00a0 alt\u0131 ile on sekiz ay aras\u0131nda geli\u015fme gerili\u011fi ba\u015flar. Sonras\u0131nda dil ve motor beceri geli\u015fmesi geriler, ama\u00e7l\u0131 el kullan\u0131m\u0131 kaybolur ve bazen mikrosefaliye kadar giden ba\u015f b\u00fcy\u00fcme h\u0131z\u0131nda azalma g\u00f6r\u00fcl\u00fcr. N\u00f6betler ve bili\u015fsel yetersizlik e\u015flik eder.<\/p>\n<div id=\"attachment_1563\" style=\"width: 2570px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-1563\" class=\"size-full wp-image-1563\" src=\"https:\/\/genoks.com.tr\/wp-content\/uploads\/2023\/04\/holding-hands-scaled.jpg\" alt=\"Rett Sendromu\" width=\"2560\" height=\"1773\" \/><p id=\"caption-attachment-1563\" class=\"wp-caption-text\">Rett Sendromu<\/p><\/div>\n<table>\n<tbody>\n<tr>\n<td><strong>Gen :<\/strong><\/td>\n<td>MECP2<\/td>\n<\/tr>\n<tr>\n<td><strong>Y\u00f6ntem :<\/strong><\/td>\n<td>T\u00fcm Gen Dizi Analizi<\/td>\n<\/tr>\n<tr>\n<td><strong>Raporlama S\u00fcresi :<\/strong><\/td>\n<td>6-8 Hafta (+\/- 2 Hafta)<\/td>\n<\/tr>\n<tr>\n<td><strong><strong>Prenatal\/ Postnatal:<\/strong><\/strong><\/td>\n<td>Postnatal<\/td>\n<\/tr>\n<tr>\n<td><strong>Gerekli Numune<\/strong>:<\/td>\n<td>EDTA&#8217;l\u0131 Kan (2-4 ml)<\/td>\n<\/tr>\n<tr>\n<td><strong>Saklama \/ Ta\u015f\u0131ma S\u0131cakl\u0131\u011f\u0131:<\/strong><\/td>\n<td>+ 4C\u00b0\/ + 24C\u00b0<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>T\u00fcm genetik testlerimiz <strong>&#8220;Hasta Onam Formu&#8221;<\/strong> ve <strong>&#8220;KVKK Formu&#8221;<\/strong>nun imzalanmas\u0131n\u0131n ard\u0131ndan \u00e7al\u0131\u015f\u0131lmaya ba\u015flan\u0131r.<\/p>\n<hr \/>\n<p><strong>Detayl\u0131 Bilgi Almak \u0130\u00e7in Bize Mesaj Atabilirsiniz.<\/strong><\/p>\n<table>\n<tbody>\n<tr>\n<td>[contact-form-7 id=&#8221;710&#8243; title=&#8221;genetik ba\u015fvuru&#8221;]<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Genoks Genetik Hastal\u0131klar De\u011ferlendirme Merkezi T.C. Sa\u011fl\u0131k Bankanl\u0131\u011f\u0131nca denetlenen ve GHDM-SM\/06.15\/01 ruhsat numaras\u0131 ile hizmet veren sa\u011fl\u0131k kurulu\u015fudur. genoks.com.tr web sayfas\u0131nda bulunan bilgiler, genetik de\u011ferlendirme ve\/veya tan\u0131-te\u015fhis ama\u00e7l\u0131 kullan\u0131lmamal\u0131d\u0131r. T\u00fcm i\u00e7erikler bilgilendirme ama\u00e7l\u0131d\u0131r.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Rett Syndrome. X-linked dominant neurodevelopmental disorder caused by mutations in the MECP2 gene, primarily affecting females (almost lethal in males prenatally). Classic features: normal early development (6-18 months), then regression with loss of purposeful hand use, stereotypic hand-wringing, gait apraxia,<span class=\"excerpt-hellip\"> [\u2026]<\/span><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","template":"","meta":{"footnotes":""},"doc_category":[204],"doc_tag":[],"class_list":["post-3320","docs","type-docs","status-publish","hentry","doc_category-genoks-gdhm-genetic-tests"],"aioseo_notices":[],"year_month":"2026-05","word_count":296,"total_views":0,"reactions":{"happy":0,"normal":0,"sad":0},"author_info":{"name":"admin","author_nicename":"admin","author_url":"https:\/\/genoks.com.tr\/en\/author\/admin\/"},"doc_category_info":[{"term_name":"Genoks GDHM Genetic Tests","term_url":"https:\/\/genoks.com.tr\/en\/docs-category\/genoks-gdhm-genetic-tests\/"}],"doc_tag_info":[],"aioseo_head":"\n\t\t<!-- All in One SEO Pro 4.9.5.2 - aioseo.com -->\n\t<meta name=\"description\" content=\"Rett Syndrome. X-linked dominant neurodevelopmental disorder caused by mutations in the MECP2 gene, primarily affecting females (almost lethal in males prenatally). Classic features: normal early development (6-18 months), then regression with loss of purposeful hand use, stereotypic hand-wringing, gait apraxia, microcephaly, seizures, autonomic dysfunction. Diagnosis: clinical criteria (Neul 2010) + MECP2 sequencing\/MLPA. Treatment: supportive multidisciplinary\" \/>\n\t<meta name=\"robots\" content=\"max-image-preview:large\" \/>\n\t<meta name=\"author\" content=\"admin\"\/>\n\t<link rel=\"canonical\" href=\"https:\/\/genoks.com.tr\/en\/docs\/rett-syndrome-en\/\" \/>\n\t<meta name=\"generator\" content=\"All in One SEO Pro (AIOSEO) 4.9.5.2\" \/>\n\t\t<meta property=\"og:locale\" content=\"en_US\" \/>\n\t\t<meta property=\"og:site_name\" content=\"Genoks Genetics | NIPT, Carrier Screening, Oncogenetics and WES Services - Shedding Light on Your Genes!\" \/>\n\t\t<meta property=\"og:type\" content=\"article\" \/>\n\t\t<meta property=\"og:title\" content=\"What is Rett Syndrome? How does it Manifest? - Genoks Genetics | NIPT, Carrier Screening, Oncogenetics and WES Services\" \/>\n\t\t<meta property=\"og:description\" content=\"Rett Syndrome. X-linked dominant neurodevelopmental disorder caused by mutations in the MECP2 gene, primarily affecting females (almost lethal in males prenatally). Classic features: normal early development (6-18 months), then regression with loss of purposeful hand use, stereotypic hand-wringing, gait apraxia, microcephaly, seizures, autonomic dysfunction. Diagnosis: clinical criteria (Neul 2010) + MECP2 sequencing\/MLPA. Treatment: supportive multidisciplinary\" \/>\n\t\t<meta property=\"og:url\" content=\"https:\/\/genoks.com.tr\/en\/docs\/rett-syndrome-en\/\" \/>\n\t\t<meta property=\"og:image\" content=\"https:\/\/genoks.com.tr\/wp-content\/uploads\/2025\/06\/genoks.svg\" \/>\n\t\t<meta property=\"og:image:secure_url\" content=\"https:\/\/genoks.com.tr\/wp-content\/uploads\/2025\/06\/genoks.svg\" \/>\n\t\t<meta property=\"article:published_time\" content=\"2025-10-06T05:52:40+00:00\" \/>\n\t\t<meta property=\"article:modified_time\" content=\"2026-05-02T05:14:21+00:00\" \/>\n\t\t<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/GenoksGHTM\" \/>\n\t\t<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n\t\t<meta name=\"twitter:site\" content=\"@Genoks_GHTM\" \/>\n\t\t<meta name=\"twitter:title\" content=\"What is Rett Syndrome? How does it Manifest? - Genoks Genetics | NIPT, Carrier Screening, Oncogenetics and WES Services\" \/>\n\t\t<meta name=\"twitter:description\" content=\"Rett Syndrome. X-linked dominant neurodevelopmental disorder caused by mutations in the MECP2 gene, primarily affecting females (almost lethal in males prenatally). Classic features: normal early development (6-18 months), then regression with loss of purposeful hand use, stereotypic hand-wringing, gait apraxia, microcephaly, seizures, autonomic dysfunction. Diagnosis: clinical criteria (Neul 2010) + MECP2 sequencing\/MLPA. Treatment: supportive multidisciplinary\" \/>\n\t\t<meta name=\"twitter:creator\" content=\"@Genoks_GHTM\" \/>\n\t\t<meta name=\"twitter:image\" content=\"https:\/\/genoks.com.tr\/wp-content\/uploads\/2025\/06\/genoks.svg\" \/>\n\t\t<script type=\"application\/ld+json\" class=\"aioseo-schema\">\n\t\t\t{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/genoks.com.tr\\\/en\\\/docs\\\/rett-syndrome-en\\\/#breadcrumblist\",\"itemListElement\":[{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/genoks.com.tr\\\/en\\\/#listItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/genoks.com.tr\\\/en\\\/\",\"nextItem\":{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/genoks.com.tr\\\/en\\\/Genoks\\\/#listItem\",\"name\":\"Dok\\u00fcmanlar\"}},{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/genoks.com.tr\\\/en\\\/Genoks\\\/#listItem\",\"position\":2,\"name\":\"Dok\\u00fcmanlar\",\"item\":\"https:\\\/\\\/genoks.com.tr\\\/en\\\/Genoks\\\/\",\"nextItem\":{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/genoks.com.tr\\\/en\\\/docs-category\\\/genoks-gdhm-genetic-tests\\\/#listItem\",\"name\":\"Genoks GDHM Genetic Tests\"},\"previousItem\":{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/genoks.com.tr\\\/en\\\/#listItem\",\"name\":\"Home\"}},{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/genoks.com.tr\\\/en\\\/docs-category\\\/genoks-gdhm-genetic-tests\\\/#listItem\",\"position\":3,\"name\":\"Genoks GDHM Genetic Tests\",\"item\":\"https:\\\/\\\/genoks.com.tr\\\/en\\\/docs-category\\\/genoks-gdhm-genetic-tests\\\/\",\"nextItem\":{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/genoks.com.tr\\\/en\\\/docs\\\/rett-syndrome-en\\\/#listItem\",\"name\":\"What is Rett Syndrome? How does it Manifest?\"},\"previousItem\":{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/genoks.com.tr\\\/en\\\/Genoks\\\/#listItem\",\"name\":\"Dok\\u00fcmanlar\"}},{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/genoks.com.tr\\\/en\\\/docs\\\/rett-syndrome-en\\\/#listItem\",\"position\":4,\"name\":\"What is Rett Syndrome? How does it Manifest?\",\"previousItem\":{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/genoks.com.tr\\\/en\\\/docs-category\\\/genoks-gdhm-genetic-tests\\\/#listItem\",\"name\":\"Genoks GDHM Genetic Tests\"}}]},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/genoks.com.tr\\\/en\\\/#organization\",\"name\":\"Genoks Genetics | NIPT, Carrier Screening, Oncogenetics and WES Services\",\"description\":\"Shedding Light on Your Genes!\",\"url\":\"https:\\\/\\\/genoks.com.tr\\\/en\\\/\",\"telephone\":\"+904448732\",\"foundingDate\":\"2014-12-01\",\"numberOfEmployees\":{\"@type\":\"QuantitativeValue\",\"value\":160},\"logo\":{\"@type\":\"ImageObject\",\"url\":\"https:\\\/\\\/genoks.com.tr\\\/wp-content\\\/uploads\\\/2025\\\/06\\\/genoks.svg\",\"@id\":\"https:\\\/\\\/genoks.com.tr\\\/en\\\/docs\\\/rett-syndrome-en\\\/#organizationLogo\",\"caption\":\"RapidNIPT testi ile yap\\u0131lan NIPT taramas\\u0131 sayesinde gebelikte 90'dan fazla kromozomal hastal\\u0131k risksiz ve erken d\\u00f6nemde tespit edilir.\"},\"image\":{\"@id\":\"https:\\\/\\\/genoks.com.tr\\\/en\\\/docs\\\/rett-syndrome-en\\\/#organizationLogo\"},\"sameAs\":[\"https:\\\/\\\/www.facebook.com\\\/GenoksGHTM\",\"https:\\\/\\\/x.com\\\/Genoks_GHTM\",\"https:\\\/\\\/www.instagram.com\\\/genoks_ghtm\\\/\",\"https:\\\/\\\/www.linkedin.com\\\/in\\\/genoks\\\/\"]},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/genoks.com.tr\\\/en\\\/author\\\/admin\\\/#author\",\"url\":\"https:\\\/\\\/genoks.com.tr\\\/en\\\/author\\\/admin\\\/\",\"name\":\"admin\",\"image\":{\"@type\":\"ImageObject\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/74da4ab1a4df3c3e843b41fd6523384c13b4e218e11eb9518da4421619941871?s=96&d=mm&r=g\"}},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/genoks.com.tr\\\/en\\\/docs\\\/rett-syndrome-en\\\/#webpage\",\"url\":\"https:\\\/\\\/genoks.com.tr\\\/en\\\/docs\\\/rett-syndrome-en\\\/\",\"name\":\"What is Rett Syndrome? How does it Manifest? - Genoks Genetics | NIPT, Carrier Screening, Oncogenetics and WES Services\",\"description\":\"Rett Syndrome. X-linked dominant neurodevelopmental disorder caused by mutations in the MECP2 gene, primarily affecting females (almost lethal in males prenatally). Classic features: normal early development (6-18 months), then regression with loss of purposeful hand use, stereotypic hand-wringing, gait apraxia, microcephaly, seizures, autonomic dysfunction. Diagnosis: clinical criteria (Neul 2010) + MECP2 sequencing\\\/MLPA. Treatment: supportive multidisciplinary\",\"inLanguage\":\"en-US\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/genoks.com.tr\\\/en\\\/#website\"},\"breadcrumb\":{\"@id\":\"https:\\\/\\\/genoks.com.tr\\\/en\\\/docs\\\/rett-syndrome-en\\\/#breadcrumblist\"},\"author\":{\"@id\":\"https:\\\/\\\/genoks.com.tr\\\/en\\\/author\\\/admin\\\/#author\"},\"creator\":{\"@id\":\"https:\\\/\\\/genoks.com.tr\\\/en\\\/author\\\/admin\\\/#author\"},\"datePublished\":\"2025-10-06T05:52:40+00:00\",\"dateModified\":\"2026-05-02T05:14:21+00:00\"},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/genoks.com.tr\\\/en\\\/#website\",\"url\":\"https:\\\/\\\/genoks.com.tr\\\/en\\\/\",\"name\":\"Genoks Genetics | NIPT, Carrier Screening, Oncogenetics and WES Services\",\"description\":\"Shedding Light on Your Genes!\",\"inLanguage\":\"en-US\",\"publisher\":{\"@id\":\"https:\\\/\\\/genoks.com.tr\\\/en\\\/#organization\"}}]}\n\t\t<\/script>\n\t\t<!-- All in One SEO Pro -->\r\n\t\t<title>What is Rett Syndrome? How does it Manifest? - Genoks Genetics | NIPT, Carrier Screening, Oncogenetics and WES Services<\/title>\n\n","aioseo_head_json":{"title":"What is Rett Syndrome? How does it Manifest? - Genoks Genetics | NIPT, Carrier Screening, Oncogenetics and WES Services","description":"Rett Syndrome. X-linked dominant neurodevelopmental disorder caused by mutations in the MECP2 gene, primarily affecting females (almost lethal in males prenatally). Classic features: normal early development (6-18 months), then regression with loss of purposeful hand use, stereotypic hand-wringing, gait apraxia, microcephaly, seizures, autonomic dysfunction. Diagnosis: clinical criteria (Neul 2010) + MECP2 sequencing\/MLPA. Treatment: supportive multidisciplinary","canonical_url":"https:\/\/genoks.com.tr\/en\/docs\/rett-syndrome-en\/","robots":"max-image-preview:large","keywords":"","webmasterTools":{"miscellaneous":""},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"BreadcrumbList","@id":"https:\/\/genoks.com.tr\/en\/docs\/rett-syndrome-en\/#breadcrumblist","itemListElement":[{"@type":"ListItem","@id":"https:\/\/genoks.com.tr\/en\/#listItem","position":1,"name":"Home","item":"https:\/\/genoks.com.tr\/en\/","nextItem":{"@type":"ListItem","@id":"https:\/\/genoks.com.tr\/en\/Genoks\/#listItem","name":"Dok\u00fcmanlar"}},{"@type":"ListItem","@id":"https:\/\/genoks.com.tr\/en\/Genoks\/#listItem","position":2,"name":"Dok\u00fcmanlar","item":"https:\/\/genoks.com.tr\/en\/Genoks\/","nextItem":{"@type":"ListItem","@id":"https:\/\/genoks.com.tr\/en\/docs-category\/genoks-gdhm-genetic-tests\/#listItem","name":"Genoks GDHM Genetic Tests"},"previousItem":{"@type":"ListItem","@id":"https:\/\/genoks.com.tr\/en\/#listItem","name":"Home"}},{"@type":"ListItem","@id":"https:\/\/genoks.com.tr\/en\/docs-category\/genoks-gdhm-genetic-tests\/#listItem","position":3,"name":"Genoks GDHM Genetic Tests","item":"https:\/\/genoks.com.tr\/en\/docs-category\/genoks-gdhm-genetic-tests\/","nextItem":{"@type":"ListItem","@id":"https:\/\/genoks.com.tr\/en\/docs\/rett-syndrome-en\/#listItem","name":"What is Rett Syndrome? How does it Manifest?"},"previousItem":{"@type":"ListItem","@id":"https:\/\/genoks.com.tr\/en\/Genoks\/#listItem","name":"Dok\u00fcmanlar"}},{"@type":"ListItem","@id":"https:\/\/genoks.com.tr\/en\/docs\/rett-syndrome-en\/#listItem","position":4,"name":"What is Rett Syndrome? How does it Manifest?","previousItem":{"@type":"ListItem","@id":"https:\/\/genoks.com.tr\/en\/docs-category\/genoks-gdhm-genetic-tests\/#listItem","name":"Genoks GDHM Genetic Tests"}}]},{"@type":"Organization","@id":"https:\/\/genoks.com.tr\/en\/#organization","name":"Genoks Genetics | NIPT, Carrier Screening, Oncogenetics and WES Services","description":"Shedding Light on Your Genes!","url":"https:\/\/genoks.com.tr\/en\/","telephone":"+904448732","foundingDate":"2014-12-01","numberOfEmployees":{"@type":"QuantitativeValue","value":160},"logo":{"@type":"ImageObject","url":"https:\/\/genoks.com.tr\/wp-content\/uploads\/2025\/06\/genoks.svg","@id":"https:\/\/genoks.com.tr\/en\/docs\/rett-syndrome-en\/#organizationLogo","caption":"RapidNIPT testi ile yap\u0131lan NIPT taramas\u0131 sayesinde gebelikte 90'dan fazla kromozomal hastal\u0131k risksiz ve erken d\u00f6nemde tespit edilir."},"image":{"@id":"https:\/\/genoks.com.tr\/en\/docs\/rett-syndrome-en\/#organizationLogo"},"sameAs":["https:\/\/www.facebook.com\/GenoksGHTM","https:\/\/x.com\/Genoks_GHTM","https:\/\/www.instagram.com\/genoks_ghtm\/","https:\/\/www.linkedin.com\/in\/genoks\/"]},{"@type":"Person","@id":"https:\/\/genoks.com.tr\/en\/author\/admin\/#author","url":"https:\/\/genoks.com.tr\/en\/author\/admin\/","name":"admin","image":{"@type":"ImageObject","url":"https:\/\/secure.gravatar.com\/avatar\/74da4ab1a4df3c3e843b41fd6523384c13b4e218e11eb9518da4421619941871?s=96&d=mm&r=g"}},{"@type":"WebPage","@id":"https:\/\/genoks.com.tr\/en\/docs\/rett-syndrome-en\/#webpage","url":"https:\/\/genoks.com.tr\/en\/docs\/rett-syndrome-en\/","name":"What is Rett Syndrome? How does it Manifest? - Genoks Genetics | NIPT, Carrier Screening, Oncogenetics and WES Services","description":"Rett Syndrome. X-linked dominant neurodevelopmental disorder caused by mutations in the MECP2 gene, primarily affecting females (almost lethal in males prenatally). Classic features: normal early development (6-18 months), then regression with loss of purposeful hand use, stereotypic hand-wringing, gait apraxia, microcephaly, seizures, autonomic dysfunction. Diagnosis: clinical criteria (Neul 2010) + MECP2 sequencing\/MLPA. Treatment: supportive multidisciplinary","inLanguage":"en-US","isPartOf":{"@id":"https:\/\/genoks.com.tr\/en\/#website"},"breadcrumb":{"@id":"https:\/\/genoks.com.tr\/en\/docs\/rett-syndrome-en\/#breadcrumblist"},"author":{"@id":"https:\/\/genoks.com.tr\/en\/author\/admin\/#author"},"creator":{"@id":"https:\/\/genoks.com.tr\/en\/author\/admin\/#author"},"datePublished":"2025-10-06T05:52:40+00:00","dateModified":"2026-05-02T05:14:21+00:00"},{"@type":"WebSite","@id":"https:\/\/genoks.com.tr\/en\/#website","url":"https:\/\/genoks.com.tr\/en\/","name":"Genoks Genetics | NIPT, Carrier Screening, Oncogenetics and WES Services","description":"Shedding Light on Your Genes!","inLanguage":"en-US","publisher":{"@id":"https:\/\/genoks.com.tr\/en\/#organization"}}]},"og:locale":"en_US","og:site_name":"Genoks Genetics | NIPT, Carrier Screening, Oncogenetics and WES Services - Shedding Light on Your Genes!","og:type":"article","og:title":"What is Rett Syndrome? How does it Manifest? - Genoks Genetics | NIPT, Carrier Screening, Oncogenetics and WES Services","og:description":"Rett Syndrome. X-linked dominant neurodevelopmental disorder caused by mutations in the MECP2 gene, primarily affecting females (almost lethal in males prenatally). Classic features: normal early development (6-18 months), then regression with loss of purposeful hand use, stereotypic hand-wringing, gait apraxia, microcephaly, seizures, autonomic dysfunction. Diagnosis: clinical criteria (Neul 2010) + MECP2 sequencing\/MLPA. Treatment: supportive multidisciplinary","og:url":"https:\/\/genoks.com.tr\/en\/docs\/rett-syndrome-en\/","og:image":"https:\/\/genoks.com.tr\/wp-content\/uploads\/2025\/06\/genoks.svg","og:image:secure_url":"https:\/\/genoks.com.tr\/wp-content\/uploads\/2025\/06\/genoks.svg","article:published_time":"2025-10-06T05:52:40+00:00","article:modified_time":"2026-05-02T05:14:21+00:00","article:publisher":"https:\/\/www.facebook.com\/GenoksGHTM","twitter:card":"summary_large_image","twitter:site":"@Genoks_GHTM","twitter:title":"What is Rett Syndrome? How does it Manifest? - Genoks Genetics | NIPT, Carrier Screening, Oncogenetics and WES Services","twitter:description":"Rett Syndrome. X-linked dominant neurodevelopmental disorder caused by mutations in the MECP2 gene, primarily affecting females (almost lethal in males prenatally). Classic features: normal early development (6-18 months), then regression with loss of purposeful hand use, stereotypic hand-wringing, gait apraxia, microcephaly, seizures, autonomic dysfunction. Diagnosis: clinical criteria (Neul 2010) + MECP2 sequencing\/MLPA. Treatment: supportive multidisciplinary","twitter:creator":"@Genoks_GHTM","twitter:image":"https:\/\/genoks.com.tr\/wp-content\/uploads\/2025\/06\/genoks.svg"},"aioseo_meta_data":{"post_id":"3320","title":null,"description":null,"keywords":null,"keyphrases":null,"primary_term":null,"canonical_url":null,"og_title":null,"og_description":null,"og_object_type":"default","og_image_type":"default","og_image_url":null,"og_image_width":null,"og_image_height":null,"og_image_custom_url":null,"og_image_custom_fields":null,"og_video":null,"og_custom_url":null,"og_article_section":null,"og_article_tags":null,"twitter_use_og":false,"twitter_card":"default","twitter_image_type":"default","twitter_image_url":null,"twitter_image_custom_url":null,"twitter_image_custom_fields":null,"twitter_title":null,"twitter_description":null,"schema":{"blockGraphs":[],"customGraphs":[],"default":{"data":{"Article":[],"Course":[],"Dataset":[],"FAQPage":[],"Movie":[],"Person":[],"Product":[],"ProductReview":[],"Car":[],"Recipe":[],"Service":[],"SoftwareApplication":[],"WebPage":[]},"graphName":"","isEnabled":true},"graphs":[]},"schema_type":"default","schema_type_options":null,"pillar_content":false,"robots_default":true,"robots_noindex":false,"robots_noarchive":false,"robots_nosnippet":false,"robots_nofollow":false,"robots_noimageindex":false,"robots_noodp":false,"robots_notranslate":false,"robots_max_snippet":null,"robots_max_videopreview":null,"robots_max_imagepreview":"large","priority":null,"frequency":null,"local_seo":null,"seo_analyzer_scan_date":"2026-05-02 06:11:45","breadcrumb_settings":null,"limit_modified_date":false,"reviewed_by":null,"open_ai":null,"ai":null,"created":"2026-05-01 14:34:37","updated":"2026-05-02 06:11:45"},"aioseo_breadcrumb":"<div class=\"aioseo-breadcrumbs\"><span class=\"aioseo-breadcrumb\">\n\t<a href=\"https:\/\/genoks.com.tr\/en\/\" title=\"Home\">Home<\/a>\n<\/span><span class=\"aioseo-breadcrumb-separator\">&raquo;<\/span><span class=\"aioseo-breadcrumb\">\n\t<a href=\"https:\/\/genoks.com.tr\/en\/Genoks\/\" title=\"Dok\u00fcmanlar\">Dok\u00fcmanlar<\/a>\n<\/span><span class=\"aioseo-breadcrumb-separator\">&raquo;<\/span><span class=\"aioseo-breadcrumb\">\n\t<a href=\"https:\/\/genoks.com.tr\/en\/docs-category\/genoks-gdhm-genetic-tests\/\" title=\"Genoks GDHM Genetic Tests\">Genoks GDHM Genetic Tests<\/a>\n<\/span><span class=\"aioseo-breadcrumb-separator\">&raquo;<\/span><span class=\"aioseo-breadcrumb\">\n\tWhat is Rett Syndrome? How does it Manifest?\n<\/span><\/div>","aioseo_breadcrumb_json":[{"label":"Home","link":"https:\/\/genoks.com.tr\/en\/"},{"label":"Dok\u00fcmanlar","link":"https:\/\/genoks.com.tr\/en\/Genoks\/"},{"label":"Genoks GDHM Genetic Tests","link":"https:\/\/genoks.com.tr\/en\/docs-category\/genoks-gdhm-genetic-tests\/"},{"label":"What is Rett Syndrome? How does it Manifest?","link":"https:\/\/genoks.com.tr\/en\/docs\/rett-syndrome-en\/"}],"_links":{"self":[{"href":"https:\/\/genoks.com.tr\/en\/wp-json\/wp\/v2\/docs\/3320","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/genoks.com.tr\/en\/wp-json\/wp\/v2\/docs"}],"about":[{"href":"https:\/\/genoks.com.tr\/en\/wp-json\/wp\/v2\/types\/docs"}],"author":[{"embeddable":true,"href":"https:\/\/genoks.com.tr\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/genoks.com.tr\/en\/wp-json\/wp\/v2\/comments?post=3320"}],"version-history":[{"count":1,"href":"https:\/\/genoks.com.tr\/en\/wp-json\/wp\/v2\/docs\/3320\/revisions"}],"predecessor-version":[{"id":3600,"href":"https:\/\/genoks.com.tr\/en\/wp-json\/wp\/v2\/docs\/3320\/revisions\/3600"}],"wp:attachment":[{"href":"https:\/\/genoks.com.tr\/en\/wp-json\/wp\/v2\/media?parent=3320"}],"wp:term":[{"taxonomy":"doc_category","embeddable":true,"href":"https:\/\/genoks.com.tr\/en\/wp-json\/wp\/v2\/doc_category?post=3320"},{"taxonomy":"doc_tag","embeddable":true,"href":"https:\/\/genoks.com.tr\/en\/wp-json\/wp\/v2\/doc_tag?post=3320"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}