{"id":3333,"date":"2025-10-06T05:52:40","date_gmt":"2025-10-06T05:52:40","guid":{"rendered":"https:\/\/genoks.com.tr\/docs\/hypogonadotropic-hypogonadism-1-sr\/"},"modified":"2026-05-02T05:14:22","modified_gmt":"2026-05-02T05:14:22","password":"","slug":"hypogonadotropic-hypogonadism-1-sr","status":"publish","type":"docs","link":"https:\/\/genoks.com.tr\/sr\/docs\/hypogonadotropic-hypogonadism-1-sr\/","title":{"rendered":"Hipogonadotropni hipogonadizam 1"},"content":{"rendered":"

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Hipogonadotropni hipogonadizam 1.<\/strong> Genetski poreme\u0107aj deficita GnRH koji dovodi do izostalog ili nepotpunog pubertetskog razvoja i neplodnosti. Vi\u0161e kauzalnih gena (KAL1\/ANOS1, FGFR1, GNRHR, GNRH1, KISS1R, TAC3, TACR3, CHD7); \u010desto povezano sa anosmijom (Kallmannov sindrom) kada su ANOS1\/FGFR1 mutirani. Hormonska zamena indukuje pubertet; pulsativna GnRH ili gonadotropinska terapija omogu\u0107uje plodnost. Genetsko testiranje vodi savetovanje o obrascu nasle\u0111ivanja (X-vezano, autozomno dominantno ili recesivno).<\/p>\n

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Hipogonadotropik Hipogonadizm 1 Nedir?<\/strong>
\nHipogonadotropik hipogonadizm 1 (HH1), Kallmann Sendromu 1 olarakta bilinen , X kromozomu \u00fczerinde bulunan ANOS1 gen mutasyonlar\u0131 sonucu \u00fcreme sistemi fonksiyonunu etkileyen bir genetik bozukluktur. Bu durumda, hipotalamus veya hipofiz bezi gibi hormonal sistemlerin d\u00fczg\u00fcn \u00e7al\u0131\u015fmamas\u0131 nedeniyle, v\u00fccutta yeterli miktarda cinsiyet hormonu \u00fcretilemez.<\/p>\n

HH1, genellikle puberte \u00f6ncesi d\u00f6nemde veya erken ergenlik d\u00f6neminde ortaya \u00e7\u0131kar. Erkeklerde, testisler normal boyutta veya k\u00fc\u00e7\u00fck olabilir ve sperm \u00fcretimi azalabilir veya durabilir. Kad\u0131nlarda, adet d\u00f6ng\u00fcs\u00fc d\u00fczensizle\u015febilir veya durabilir ve do\u011furganl\u0131k azalabilir. HH1, ayn\u0131 zamanda cinsel geli\u015fimde gecikmelere neden olabilir. Baz\u0131 durumlarda hastal\u0131\u011fa koku kayb\u0131 ve i\u015fitme kayb\u0131 e\u015flik edebilir.<\/p>\n

HH1, hormonal testler ve genetik testlerle te\u015fhis edilebilir. Tedavi, hormon replasman tedavisi ile ger\u00e7ekle\u015ftirilir. Bu tedavi, cinsiyet hormonu eksikli\u011fini tedavi ederek, adet d\u00f6ng\u00fcs\u00fcn\u00fc d\u00fczenleyerek ve cinsel geli\u015fimi te\u015fvik ederek semptomlar\u0131 iyile\u015ftirebilir.<\/p>\n\n\n\n\n\n\n\n\n
Gen :<\/strong><\/td>\nANOS1<\/td>\n<\/tr>\n
Y\u00f6ntem :<\/strong><\/td>\nT\u00fcm Gen Dizi Analizi<\/td>\n<\/tr>\n
Raporlama S\u00fcresi :<\/strong><\/td>\n6-8 Hafta (+\/- 2 Hafta)<\/td>\n<\/tr>\n
Prenatal\/ Postnatal:<\/strong><\/strong><\/td>\nPostnatal<\/td>\n<\/tr>\n
Gerekli Numune<\/strong>:<\/td>\nEDTA’l\u0131 Kan (2-4 ml)<\/td>\n<\/tr>\n
Saklama \/ Ta\u015f\u0131ma S\u0131cakl\u0131\u011f\u0131:<\/strong><\/td>\n+ 4C\u00b0\/ + 24C\u00b0<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

T\u00fcm genetik testlerimiz „Hasta Onam Formu“<\/strong> ve „KVKK Formu“<\/strong>nun imzalanmas\u0131n\u0131n ard\u0131ndan \u00e7al\u0131\u015f\u0131lmaya ba\u015flan\u0131r.<\/p>\n

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Detayl\u0131 Bilgi Almak \u0130\u00e7in Bize Mesaj Atabilirsiniz.<\/strong><\/p>\n\n\n\n
[contact-form-7 id=“710″ title=“genetik ba\u015fvuru“]<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Genoks Genetik Hastal\u0131klar De\u011ferlendirme Merkezi T.C. Sa\u011fl\u0131k Bankanl\u0131\u011f\u0131nca denetlenen ve GHDM-SM\/06.15\/01 ruhsat numaras\u0131 ile hizmet veren sa\u011fl\u0131k kurulu\u015fudur. genoks.com.tr web sayfas\u0131nda bulunan bilgiler, genetik de\u011ferlendirme ve\/veya tan\u0131-te\u015fhis ama\u00e7l\u0131 kullan\u0131lmamal\u0131d\u0131r. T\u00fcm i\u00e7erikler bilgilendirme ama\u00e7l\u0131d\u0131r.<\/p>\n","protected":false},"excerpt":{"rendered":"

Hipogonadotropni hipogonadizam 1. Genetski poreme\u0107aj deficita GnRH koji dovodi do izostalog ili nepotpunog pubertetskog razvoja i neplodnosti. Vi\u0161e kauzalnih gena (KAL1\/ANOS1, FGFR1, GNRHR, GNRH1, KISS1R, TAC3, TACR3, CHD7); \u010desto povezano sa anosmijom (Kallmannov sindrom) kada su ANOS1\/FGFR1 mutirani. Hormonska zamena [\u2026]<\/span><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","template":"","meta":{"footnotes":""},"doc_category":[208],"doc_tag":[],"class_list":["post-3333","docs","type-docs","status-publish","hentry","doc_category-genoks-gdhm-genetic-tests-sr"],"aioseo_notices":[],"year_month":"2026-05","word_count":345,"total_views":0,"reactions":{"happy":0,"normal":0,"sad":0},"author_info":{"name":"admin","author_nicename":"admin","author_url":"https:\/\/genoks.com.tr\/sr\/author\/admin\/"},"doc_category_info":[{"term_name":"\u0413\u0435\u043d\u0435\u0442\u0441\u043a\u0438 \u0442\u0435\u0441\u0442\u043e\u0432\u0438 Genoks GDHM","term_url":"https:\/\/genoks.com.tr\/sr\/docs-category\/genoks-gdhm-genetic-tests-sr\/"}],"doc_tag_info":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t